Vitamin D3 1400 IU

Vitamin D3 (cholecalciferol) is a fat-soluble secosteroid prohormone synthesised in the skin upon UVB irradiation and converted sequentially to 25-hydroxyvitamin D and then to the active 1,25-dihydroxyvitamin D (calcitriol). The vitamin D receptor (VDR) is expressed in virtually every nucleated cell and regulates over 200 genes governing calcium absorption, phosphate metabolism in bone, innate and adaptive immune cell differentiation, and myocyte proliferation. Vitamin D insufficiency affects an estimated 1 billion people globally, making regular supplementation essential for most individuals in northern latitudes or with limited sun exposure. The 1400 IU dose provides a physiologically relevant daily input suitable for maintenance of adequate serum 25(OH)D levels in most adults.