Bionetic
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Bionetic
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Bionetic
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Synephrine is a phenethylamine alkaloid derived from Citrus aurantium (bitter orange) peel that selectively agonises beta-3 adrenergic receptors on adipocytes and thermogenic brown adipose tissue. Unlike its structural analog ephedrine, synephrine has minimal affinity for alpha-1, beta-1, and beta-2 receptors — explaining its thermogenic and lipolytic efficacy with a substantially lower cardiovascular risk profile. Multiple clinical trials demonstrate that synephrine increases resting metabolic rate by 65–183 kcal/day and enhances fat oxidation during exercise, particularly effective when combined with hesperidin and naringenin. The EFSA has assessed synephrine as safe at doses up to 49 mg per day in healthy adults.
Key Capabilities
Supplement Facts
| Per serving | |
|---|---|
| Bitter orange fruit extract (Citrus aurantium L.), standardised to 30% synephrine | 67 mg |
| of which p-synephrine | 20 mg |
Other ingredients: Capsule shell: gelatin; anti-caking agent: magnesium salts of fatty acids; bulking agent: microcrystalline cellulose.
Key Features
Selective beta-3 adrenergic agonist — thermogenic with low cardiovascular risk
Increases resting metabolic rate by 65–183 kcal/day in clinical trials
Enhances fat oxidation during aerobic exercise
Synergistic with hesperidin and naringenin from bitter orange
EFSA-assessed safe at doses up to 49 mg/day in healthy adults
Appetite modulation via adrenergic satiety signalling
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